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apalutamide will lessen the extent or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medicines that happen to be CYP3A4 substrates may end up in lessen publicity to these remedies.If you're taking codeine as being a l